Publication list

Van Haute L, et al. (2024) Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease. EMBO Mol Med

Lambros M, Moreno J, Fei Q, Parsa C, Orlando R & Van Haute L. (2023) Transcriptome sequencing reveals the mechanism behind the chemically induced oral mucositis in a 3D cell culture model. IJMS 24(5):5058

Van Haute L, et al. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nat Commun

Van Haute L, et al. (2021) Detection of 5-formylcytosine in mitochondrial transcriptome. Methods Mol Biol 2192:59-68

Van Haute L, et al. (2019) METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res 47(19):10267-10281

Van Haute L, et al. (2019) NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Nucleic Acids Res 47(16):8720-8733

Van Haute L, et al. (2017) Dealing with an unconventional genetic code in mitochondria: the biogenesis and pathogenic defects of the 5-formylcytosine modification in mitochondrial tRNAMet. Biomolecules 7(1):24

Van Haute L, et al. (2016) Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3. Nat Commun 7:12039

Van Haute L, et al. (2015) Mitochondrial transcript maturation and its disorders. J Inherit Metab Dis 38:655-80

Van Haute L, et al. (2013) Human embryonic stem cells commonly display large mitochondrial DNA deletions. Nat Biotechnol 31:20-3

Van Haute L, et al. (2011) Generation of Lung Epithelial-Like Tissue from hESC by Air–Liquid Interface Culture. Springer Protocol Handbooks. Human Embryonic and Induced Pluripotent Stem Cells. 405-411.

Van Haute L, et al. (2009) Generation of lung epithelial-like tissue from human embryonic stem cells. Respir Res 10:105

Other publications

Mutti C, et al. (2024) The catalytic activity of methyltransferase METTL15 is dispensable for its role in mitochondrial ribosome biogenesis. RNA Biology 21(1):23-30

Silva-Pinheiro P, et al. (2022) A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome. Nat Biomed Eng

Rebelo-Guiomar P, et al. (2022) A late-stage assembly checkpoint of the human mitochondrial ribosomal large subunit. Nat commun 13(1):929

Silva-Pinheiro P, et al. (2022) In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue. Nat commun 18(1):750

Ohkubo A, et al. (2021) The FASTK family proteins fine-tune mitochondrial RNA processing. PloS Genet 17(11):e1009873

D’Souze AR, et al. (2021) YbeY is required for ribosomal small subunit assembly and tRNA processing in human mitochondria. Nucleic Acids Res 49(10):5798-5812

Palenikova P, et al. (2021) Quantitative density gradient analysis by mass spectrometry (qDGMS) and complexome profiling analysis (ComPrAn) R package for the study of macromolecular complexes. Biochim Biophys Acta Bioenrg 1862(6):148399

Park, et al. (2019) The structure of human EXD2 reveals a chimeric 3’ t 5’ exonuclease domain that discriminates substrates via metal coordination. Nucleic Acids Res 47(13):7078-7093

Rebelo-Guimar P, et al. (2019) The mammalian mitochondrial epitranscriptome. Biochim Biophys Acta Gene Regul Mech 1862(3):429-446

Hoitzing H, et al. (2019) Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations. PLoS Comput Biol 1(6):e1007023

Gammage PA, et al. (2018) Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nat Med 24(11):1691-1695

Pearce SF, et al. (2017) Maturation of selected human mitochondrial tRNAs requires deadenylation. Elife 6:e27596

Gammage PA, et al. (2016) Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic Acids Res 44(16):7804-16

Geens M, et al. (2016) Female human pluripotent stem cells rapidly lose X chromosome inactivation marks and progress to a skewed methylation pattern during culture. Mol Hum Reprod 4:285-98

Karniely S, et al. (2016) Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries. MBio 7:2

Gammage PA, et al. (2016) Engineered mtZFN's for Manipulation of Human Mitochondrial DNA Heteroplasmy. Methods Mol Biol 1351:145-62

Spits C, et al. (2006) Whole-genome multiple displacement amplification from single cells. Nat Protoc. 1:1965-70.

Spits C, et al. (2006) Optimization and evaluation of single-cell whole-genome multiple displacement amplification. Hum Mutat. 27:496-503.

De Vriese AS, et al. (2006) Linezolid-induced inhibition of mitochondrial protein synthesis.  Clin Infect Dis. 15:1111-7